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    Isotretinoin is a form of vitamin A. It reduces the amount of oil released by oil glands in your skin, and helps your skin renew itself more quickly. Isotretinoin is used to treat severe nodular acne that has not responded to other treatments, including antibiotics.
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    The recommended dosage range for Accutane is 0.5 to 1.0 mg/kg/day given in two divided doses with food for 15 to 20 weeks. In studies comparing 0.1, 0.5, and 1.0 mg/kg/day,8 it was found that all dosages provided initial clearing of disease, but there was a greater need for retreatment with the lower dosages.
    Isotretinoin (13-cis retinoic acid) is a vitamin-A derivative (retinoid). The liver naturally makes small quantities of isotretinoin from vitamin-A, but the drug we prescribe is made synthetically. Isotretinoin was developed in the 1950s, but only started being used in the mid 1970s.
    A standard course of therapy is 16 to 20 weeks. At the end of 16 weeks, about 85% of patients are clear. The beneficial effects of Accutane do not stop when the drug is discontinued. A further reduction of acne lesions and improvement of scarring is seen for months after treatment has stopped.
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    Accutane is linked to serious side effects like birth defects, thoughts of suicide, depression and bowel disorders. ... Although the drug was hailed by dermatologists as a breakthrough treatment for patients with severe acne, Accutane's dangerous side effects affected thousands of patients during the past 30 years
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    The bad news is that if it isn't used correctly there can be serious side effects. Accutane can cause severe birth defects. ... Note, Accutane is NOT anabolic steroids, and should not be considered in the same drug category. It's an anti-acne medication.
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