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    To grow and reproduce, breast cancer cells require the female hormone estrogen. Tamoxifen is an "anti-estrogen" and works by competing with estrogen to bind to estrogen receptors in breast cancer cells. Tamoxifen is formally known as a selective estrogen receptor modulator (SERM).
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    Nolvadex (tamoxifen citrate) is a nonsteroidal antiestrogen used to treat breast cancer that has spread to other parts of the body (metastatic breast cancer), to treat breast cancer in certain patients after surgery and radiation therapy, and to reduce the chances of breast cancer in high-risk patients.
    This drug is not a SERM – it acts like an anti-estrogen throughout the body. Fulvestrant is used to treat metastatic breast cancer, most often after other hormone drugs (like tamoxifen and often an aromatase inhibitor) have stopped working. It is given by injections into the buttocks.
    Tamoxifen is used to treat breast cancer that has spread to other parts of the body in men and women. It is used to treat early breast cancer in women who have already been treated with surgery, radiation, and/or chemotherapy. ... It blocks the activity of estrogen (a female hormone) in the breast.
    Tamoxifen is used to prevent and treat breast cancers that test positive for estrogen receptors (ER+). It blocks the effects that the hormone estrogen has on cancer cells and lowers the chance that breast cancer will grow. Tamoxifen: Has been used for decades to treat patients with advanced breast cancer.
    Hormone therapy drugsFigure 5.7: Hormone therapies commonly used to treat early and locally advanced breast cancerDrug Brand name Used in pre- or postmenopausal women?Tamoxifen Nolvadex Pre- and postmenopausalAnastrozole Arimidex PostmenopausalLetrozole Femara Postmenopausal3 more rows
    Nolvadex (Tamoxifen Citrate) use with Anabolic Steroids. Nolvadex, or Tamoxifen Citrate is a prescription drug that is used to treat breast cancer in both men and women. It can also be used as a preventive measure for women more likely to develop breast cancer due to age, genetics, or other high risk factors.
    Tamoxifen is a drug that binds to your estrogen receptors. ... However, Tamoxifen has been found to cause cancer instead. According to a study published in the International Journal of Gynecological Cancer, the treatment of breast cancer with tamoxifen results in an increased risk of uterine cancer incidence and mortality.
    Tamoxifen blocks the actions of estrogen, a female hormone. Certain types of breast cancer require estrogen to grow. Tamoxifen is used to treat some types of breast cancer in men and women.
    What do hormone blockers do to get rid of breast cancer? The most common hormone therapy drug is Tamoxifen. It blocks the estrogen-shaped openings in the cells, preventing estrogen-fueled cancers from growing. Tamoxifen can be taken as a pill on a daily basis, up to five years after surgery.
    It is also soluble in methanol, ethanol, 2-propanol and propylene glycol. Stock solutions of tamoxifen can also be prepared in DMSO at 10 mM. However, it is practically insoluble in water (solubility is <0.01%, 20° C).
    Selective estrogen receptor modulators (SERMs) bind to estrogen receptors, preventing estrogen from binding. Examples of SERMs approved by the FDA are tamoxifen (Nolvadex®), raloxifene (Evista®), and toremifene (Fareston®). Tamoxifen has been used for more than 30 years to treat hormone receptor-positive breast cancer.
    Some women may take tamoxifen for 5 years. Other women may take it for 2 or 3 years and then switch to an aromatase inhibitor. Depending on your unique situation, your doctor may recommend that you take tamoxifen for a longer or shorter amount of time.
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